|
|
5beta-cholestan-3-one + NADP+ <=> H+ + cholest-4-en-3-one + NADPH
|
1.3.1.3
Delta4-3-oxosteroid 5beta-reductase
|
–
|
|
|
BRENDA:
BR36805
KEGG:
R02609
MetaCyc:
CHOLESTENONE-5-BETA-REDUCTASE-RXN
|
|
|
|
cholest-4-en-3-one + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> (25S)-26-hydroxycholest-4-en-3-one + H2O + oxidized_ferredoxin
|
1.14.15.29
cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]
|
–
|
M
|
|
BRENDA:
BR51664
KEGG:
R09859
MetaCyc:
RXN-12848
|
|
|
|
cholest-4-en-3-one + reduced_ferredoxin_[iron-sulfur]_cluster + H+ + O2 <=> (25S)-3-oxocholest-4-en-26-oate + oxidized_ferredoxin + H2O
|
1.14.15.29
cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]
|
–
|
K
|
|
BRENDA:
BR51666
KEGG:
R11357
MetaCyc:
RXN-17644
|
|
|
|
5-Cholesten-3-one <=> cholest-4-en-3-one
|
5.3.3.1
steroid Delta-isomerase
|
–
|
M
|
|
BRENDA:
BS1075
MetaCyc:
RXN-12694
|
|
|
|
O2 + cholesterol <=> cholest-4-en-3-one + H2O2
|
1.1.3.6
cholesterol oxidase
|
–
|
K
|
|
BRENDA:
BS188843
KEGG:
R01459
MetaCyc:
CHOLESTEROL-OXIDASE-RXN
|
|
|
|
5alpha-Cholestan-3-one + NADP+ <=> cholest-4-en-3-one + NADPH + H+
|
1.3.1.22
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
|
–
|
|
|
BRENDA:
BS260951
KEGG:
R02610
MetaCyc:
CHOLESTENONE-5-ALPHA-REDUCTASE-RXN
|
|
|
|
cholest-4-en-3-one + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> (25R)-26-hydroxycholest-4-en-3-one + H2O + oxidized_ferredoxin
|
1.14.15.29
cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]
|
–
|
M
|
|
BRENDA:
BS417921
MetaCyc:
RXN-17646
|
|
|
|
cholest-4-en-3-one + 6 [2Fe-2S]-center + 3 O2 <=> (25R)-3-oxocholest-4-en-26-oate + 6 [2Fe-2S]-center + 4 H2O
|
1.14.15.28
cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]
|
–
|
K
|
|
BRENDA:
BR51696
KEGG:
R11361
|
|
|
|
cholest-4-en-3-one + 2 [2Fe-2S]-center + O2 <=> (25R)-26-hydroxycholest-4-en-3-one + 2 [2Fe-2S]-center + H2O
|
1.14.15.28
cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]
|
–
|
|
|
BRENDA:
BR51697
KEGG:
R11358
|
|
|
|
cholesterol + NAD+ <=> cholest-4-en-3-one + NADH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
5.3.3.1
steroid Delta-isomerase
|
–
–
|
K
|
|
KEGG:
R09920
|
|
|
|
cholest-4-en-3-one + acceptor <=> cholesta-1,4-dien-3-one + reduced_acceptor
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
|
|
MetaCyc:
RXN-12690
|
|
|
|
cholest-4-en-3-one + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> (25R)-3-oxocholest-4-en-26-oate + H2O + oxidized_ferredoxin
|
1.14.15.28
cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]
|
–
|
|
|
MetaCyc:
RXN-17649
|
|
|
|
cholest-4-en-3-one + H2O + acceptor <=> 25-hydroxycholest-4-en-3-one + reduced_acceptor
|
1.17.99.e
|
–
|
M
|
|
MetaCyc:
RXN-21430
|
|
|
|
cholest-4-en-3-one + 2 reduced_ferredoxin_[iron-sulfur]_cluster + 2 H+ + O2 <=> 9alpha-hydroxycholest-4-en-3-one + 2 oxidized_ferredoxin + H2O
|
1.14.15.30
3-ketosteroid 9alpha-monooxygenase
|
–
|
|
|
BRENDA:
BS418294
|
|
|
|
cholest-4-en-3-one + 3 NADH + 3 H+ + 3 O2 <=> (25S)-3-oxocholest-4-en-26-oate + 3 NAD+ + 4 H2O
|
1.14.15.29
cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]
|
–
|
|
|
BRENDA:
BR49973
|
|
|
|
cholest-4-en-3-one + 6 [2Fe-2S]-center <=> (25R)-3-oxocholest-4-en-26-oate + 6 [2Fe-2S]-center + 4 H2O
|
1.14.15.28
cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]
|
–
|
|
|
BRENDA:
BS436427
|
|